Pineal allopregnanolone saves cerebellar Purkinje cells from apoptosis
نویسندگان
چکیده
منابع مشابه
Oleuropein Attenuates Deltamethrin-induced Apoptosis in Rat Cerebellar Purkinje Neurons
Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. This study aimed at determining the DM toxicity and anti-apoptotic effect of OE pretreatment in cerebellar Purkinje neurons. Materials and Methods: Rats were randomly divided into four groups a...
متن کاملBiosynthesis and biological action of pineal allopregnanolone
The pineal gland transduces photoperiodic changes to the neuroendocrine system by rhythmic secretion of melatonin. We recently provided new evidence that the pineal gland is a major neurosteroidogenic organ and actively produces a variety of neurosteroids de novo from cholesterol in birds. Notably, allopregnanolone is a major pineal neurosteroid that is far more actively produced in the pineal ...
متن کاملoleuropein attenuates deltamethrin-induced apoptosis in rat cerebellar purkinje neurons
background: deltamethrin (dm) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. there is accumulating evidence that oleuropein (oe) has anti-apoptotic effect. this study aimed at determining the dm toxicity and anti-apoptotic effect of oe pretreatment in cerebellar purkinje neurons. materials and methods: rats were randomly divided into four groups as f...
متن کاملInverse Stochastic Resonance in Cerebellar Purkinje Cells
Purkinje neurons play an important role in cerebellar computation since their axons are the only projection from the cerebellar cortex to deeper cerebellar structures. They have complex internal dynamics, which allow them to fire spontaneously, display bistability, and also to be involved in network phenomena such as high frequency oscillations and travelling waves. Purkinje cells exhibit type ...
متن کاملA computer model of cerebellar Purkinje cells.
A mathematical computer model of frog Purkinje cells is generated on the basis of presentday morphological and physiological data. The mode1 utilizes passive cable equations and the Hodgkin & Huxley equations describing ionic conductances in excitable membranes. It comprises 62 compartments, the active and passive properties being specified independently for each compartment. The morphological ...
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ژورنال
عنوان ژورنال: Electrophoresis Letters
سال: 2019
ISSN: 2189-2628,2189-2636
DOI: 10.2198/electroph.63.19